Trazodone and Weight Changes - Drugsdb. Trazodone is classified as an antidepressant drug, specifically a serotonin modulator. It works in the brain by increasing the amounts of serotonin, a neurotransmitter or brain chemical required for mental function. Trazodone and Weight Gain. Trazodone can cause a number of side effects, and weight gain is one of the reported side effects. Although it is not fully understood how trazodone causes this weight change, medical experts believe that it is due to a variety of biochemical mechanisms and pharmacologic effects of the drug. Like other antidepressant drugs, trazodone can increase the appetite of a person. Usually, loss of appetite is a symptom of depression, so once depression is relieved the person’s appetite is restored. In patients whose depression symptom is accompanied by loss of appetite, a gradual increase in weight may be expected. In some patients, antidepressant drugs lead to craving for certain types of foods such as fat or carbohydrates. Many medical experts believe that the increase in serotonin levels lead to increased appetite. In clinical studies, weight gain has been reported by about 4. It is therefore considered as a “common” side effect which means that it can occur in more than 1 percent of patients taking this drug. What to do. Usually, trazodone- induced weight gain is not a major problem. In some patients, weight gain is beneficial. Lifestyle changes such as having a healthy diet, regular exercise and limiting alcohol intake often helps reduce or prevent weight gain. However, sudden or uncontrolled weight gain may signal other underlying medical conditions. In case you experience uncontrolled weight gain despite lifestyle changes, you should consult your healthcare provider. Trazodone and Weight Loss. The exact effect of trazodone on the person’s body weight is quite complex. In some people, this antidepressant drug causes weight loss instead of weight gain. In fact, some studies suggest that weight loss is more common, occurring to about 5. In some patients, the weight loss is just temporary which eventually leads to weight gain after long- term use. It is not entirely clear how trazodone causes weight loss. There are some patients who find eating as a defense mechanism to cope up with the depression. Once their depression is relieved, they regain the normal eating pattern and gradual weight loss becomes evident. Weight gain is a common symptom of depression hence weight loss can be a welcome change for some patients. In some patients, trazodone can cause gastrointestinal side effects such as diarrhea, nausea and loss of appetite, which may lead to weight loss. These side effects often resolve with time. However, if you lose too much weight, you should consult your healthcare provider. Every patient may react differently to trazodone. It is best to discuss with your healthcare provider any signs of weight change. Prescription weight- loss drugs: Can they help you? Common weight- loss drugs. The chart shows the currently available prescription weight- loss drugs, how they work and their side effects. Drug. Mechanism of action. Possible side effects. Benzphetamine (Didrex)Decreases appetite, increases feeling of fullness. Increased blood pressure and heart rate, nervousness, insomnia, dry mouth, constipation. Diethylpropion (Tenuate)Decreases appetite, increases feeling of fullness. Headache, increased blood pressure and heart rate, nervousness, insomnia, dry mouth, constipation. Lorcaserin (Belviq)Decreases appetite, increases feeling of fullness. Headache, nausea, dry mouth, dizziness, fatigue, constipation. Naltrexone and bupropion extended- release (Contrave)Decreases appetite, increases feeling of fullness. Nausea, constipation, headache, vomiting, dizziness. Phendimetrazine. Decreases appetite, increases feeling of fullness. Increased blood pressure and heart rate, nervousness, insomnia, dry mouth, constipation. Phentermine (Adipex- P, Suprenza)Decreases appetite, increases feeling of fullness. Headache, increased blood pressure and heart rate, nervousness, insomnia, dry mouth, constipation. Orlistat (Xenical)Blocks absorption of fat. Decreased absorption of fat- soluble vitamins, oily spotting, intestinal cramps, gas with discharge, diarrhea, fecal urgency and incontinence. Phentermine and topiramate extended- release (Qsymia)Decreases appetite, increases feeling of fullness. Insomnia, dry mouth, dizziness, constipation, pins and needles feeling, changes in sense of taste or smell. Liraglutide (Saxenda)Slows gastric emptying, increases feeling of fullness. Nausea, vomiting, pancreatitis. Safety of weight- loss drugs. Drugs for short- term use. Diethylpropion (Tenuate), phentermine (Adipex- P), benzphetamine (Didrex) and phendimetrazine are approved for only short- term use — generally less than 1. These drugs are classified as controlled substances because they have the potential to be abused. Because of possible side effects, these drugs aren't recommended if you have heart disease, high blood pressure or hyperthyroidism. Drugs for long- term use. Orlistat (Xenical), lorcaserin (Belviq), phentermine- topiramate (Qsymia), naltrexone- bupropion (Contrave) and liraglutide (Saxenda) are approved for long- term use. Orlistat is also available in a reduced- strength form without a prescription (Alli). Limiting your intake of dietary fat is critical when taking orlistat to minimize side effects. After orlistat was approved, rare cases of serious liver injury were reported in some people taking it. No cause- and- effect relationship was established. However, Xenical and Alli labels now advise people taking orlistat to be alert to signs and symptoms that could indicate liver injury, such as itching, loss of appetite, yellow eyes or skin, light- colored stool, or brown urine. Lorcaserin (Belviq) initially raised concerns because it works somewhat like fenfluramine — which was withdrawn from the market because it damaged heart valves. However, there is no evidence that Belviq damages heart valves. Belviq may increase heart rate, so people taking it may need to have their heart rate checked. The combination drug Qsymia (phentermine and topiramate) increases the risk of birth defects. Thus, the Food and Drug Administration (FDA) required the manufacturer to have a risk evaluation and mitigation strategy (REMS). The REMS is intended to alert women to the risks and explain the need to avoid becoming pregnant while taking Qsymia. In addition, Qsymia is considered a controlled substance because one of its ingredients — phentermine — has the potential for abuse. The combination drug Contrave contains naltrexone and bupropion. Naltrexone is used to treat alcohol and opioid dependence, while bupropion is an antidepressant that often reduces the risk of weight gain in people who are trying to quit smoking. Contrave also can raise heart rate and blood pressure and may increase the risk of seizures. Bupropion can increase the risk of suicidal thoughts and behaviors. Liraglutide (Saxenda) is the newest drug to be approved for weight loss. The FDA approved it with the requirement that the manufacturer have a REMS to inform doctors about the serious risks associated with Saxenda. Saxenda has a boxed warning stating that tumors of the thyroid gland have been observed in animal studies but that it is unknown whether Saxenda causes these tumors in humans. Unlike the other weight- loss drugs, Saxenda is administered by injection once daily. Factors to consider. Find patient medical information for Celexa Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. What is the most important information I should know about phentermine (Ionamin)? Weight loss during pregnancy can harm an unborn baby, even if you are overweight.
If you meet the criteria for prescription weight- loss drugs, you and your doctor will need to evaluate the potential benefits against the possible risks of taking the medicine. Cost also is a consideration. Not all health insurance plans cover prescription weight- loss drugs. Adverse effects are common with weight- loss drugs, which may make it hard to stick with treatment. As you consider weight- loss drugs, make sure that you make every effort to exercise, change your eating habits and adjust any other lifestyle factors that have contributed to your excess weight. Weight- loss drugs aren't the easy answer to weight loss, but they can be a useful tool to help you make the necessary diet and lifestyle changes. Keeping off the pounds you've lost, however, is an ongoing concern. And many people, despite their efforts, still regain the weight. April 3. 0, 2. 01. Ask. Mayo. Expert. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2. Bray GA, et al. Obesity in adults: Drug therapy. Accessed Jan. 2. 7, 2. Padwal RS, et al. Drug treatments for obesity: Orlistat, sibutramine and remonabant. Rucker D, et al. Long term pharmacotherapy for obesity and overweight: Updated meta- analysis. Meridia (sibutramine): Market withdrawal due to risk of serious cardiovascular events. Food and Drug Administration. Accessed April 1. Completed safety review of Xenical/Alli (orlistat) and severe liver injury. Food and Drug Administration. Accessed April 1. Xenical (prescribing information). South San Francisco, Calif.: Genentech USA, Inc.; 2. Accessed April 1. Belviq (prescribing information). San Diego, Calif.: Arena Pharmaceuticals; 2. Accessed April 1. FDA approves Belviq to treat some overweight or obese adults. Food and Drug Administration. Accessed April 1. FDA approves weight- management drug Qsymia. Food and Drug Administration. Accessed April 1. Qsymia (prescribing information). Mountain View, Calif.: Vivus Inc.; 2. Accessed April 1. Pollack A. FDA approves Qsymia, a weight- loss drug. New York Times. Accessed April 1. Allison DB, et al. Controlled- release phentermine/topiramate in severely obese adults: A randomized controlled trial (EQUIP). Medications target long- term weight control. Food and Drug Administration. Accessed April 1. Publication in Federal Register tomorrow moves Belviq (lorcaserin) closer to launch. Accessed April 1. Didrex (prescribing information). New York., N. Y.: Pharmacia and Upjohn; 2. Accessed April 1. Suprenza (prescribing information). Cranford, N. J.: Akrimas; 2. Accessed April 1. Tenuate (prescribing information). Parsippany, N. J.: Actavis Pharma, Inc., 2. Accessed April 1. Bontril (prescribing information). Princeton, N. J.: Sandoz Pharmaceuticals, 2. Accessed April 1. Contrave (prescribing information). Deerfield, Ill.: Takeda Pharmaceuticals America; 2. Accessed April 1. FDA approves weight- management drug Contrave. Food and Drug Administration. Accessed April 1. Apovian CM, et al. Guidelines on pharmacological management of obesity: An Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism. FDA approves weight- management drug Saxenda. Food and Drug Administration. Accessed April 1. Saxenda (prescribing information). Plainsboro, N. J.: Novo Nordisk; 2. Accessed April 1. Murphy JA, et al. Drugs in perspective: Liraglutide for the treatment of obesity. Formulary Watch. Accessed April 1. See more In- depth.
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